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  • Writer's pictureAdam Whatley

Biostimulation of Knee Cartilage Using Autologous Micro-grafts

Updated: Feb 29

Knee stem cell treatment Birmingham

Cartilage injuries often result from trauma or sports injuries, or be the consequence of cartilage degeneration conditions, such as chondromalacia and osteoarthritis.

Whatever the cause may be, the loss of cartilage causes pain and physical disability. The traditional management of degenerative cartilage diseases is based on physical therapy, pain relief and surgery if required. However, many patients unfortunately do not respond well to the above. Furthermore, cartilage degradation is unfortunately progressive meaning it will continue to get worse with time, with the additional fact that the worse it becomes the harder it is to treat.

In the recent years, many efforts have been made in developing new strategies aimed at cartilage preservation and regeneration. In addition to the use of hyaluronic acid Injection, various approaches have been proposed in regenerative medicine to stimulate the production of new cartilage a process called chrondrogensis. Biostimulation and biological approaches, such as autologous chondrocyte implantation and the use of platelet-rich plasma to stimulate the production of new cartilage are widely used with good success.

The Regenera Activa Micrograft treatment is an advanced new strategy in regenerative medicine which allows obtaining autologous micro-grafts enriched with mesenchymal stem cells. Compared to additional techniques, this process has claimed to be faster and safer. To date, the Regenera Activa Micrograft treatment has shown excellent clinical efficacy in the management of a variety of conditions.

In the clinical study below, the clinical and functional outcomes of cartilage autologous micro-grafting in patients with knee cartilage injuries have served very good.


Autologous Micro-Graft Transfer

15 days before the intervention, patients started treatment with chondroitin sulfate and supplementary vitamin C and zinc. Patients with low levels of vitamin D3 and B12 were also supplemented with these vitamins. Non-steroidal anti-inflammatory drugs were excluded for 15 days prior.

The tiny cartilage graft was obtained from the auricle cartilage of the ear to the target knee. The cartilage graft was excised microsurgery scissors. The perichondrial tissue surrounding the cartilage gap was scratched and added to the sample.

The sample is then mechanically disaggregated using the Regenera Activa protocol. The system was previously analyzed by Svolacchia et al., who found the following percentages of mesenchymal stem cells markers: 82% of CD34, 82% of CD90 (Thy-1), and 53% of CD105 [23]. Disaggregated regenerative cells are then finally injected into the knee.

A specific rehabilitation programe is then adopted and monitored.

The use of autologous grafts enriched in mesenchymal stem cells has resulted in increased healing or of cartilage defects visible on MRI. After graft transfer patients have shown reduced swelling alongside improved function and pain.

In summary, the study has identified that the transfer of autologous micro-grafts using the Rigenera protocol is safe and has promising results in the treatment of cartilage injuries associated with pain and functional limiting.


Don’t let knee pain, joint damage, sports injuries or arthritis get in the way of allowing you to do what you want. Schedule a consultation at Dynamic Osteopaths today, and let us treat your injury, provide pain relief and get you back to your full and active lifestyle. We have clinics operating out of Solihull (Henley-In-Arden), Birmingham (Harborne/Edgbaston) & Bromsgrove (Barnt Green).

Call us today 01564 330773

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